Differential sensitivity of antinociceptive tests to opioid agonists and partial agonists
نویسندگان
چکیده
منابع مشابه
Potency ratio between opioid agonists and partial agonists.
POTENCY RATIO BETWEEN OPIOID AGONISTS AND PARTIAL AGONISTS Sir,—The paper by Klepper and colleagues (1986) again seems to indicate the belief of this group of workers in a fixed potency ratio between opioid agonists and partial agonists, although such a concept is theoretically unlikely (Kay, 1985). Support for a variable potency ratio is apparent in their paper, however, in that nalbuphine in ...
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BACKGROUND The opioid receptor antagonists naloxone and naltrexone are competitive antagonists at the mu, kappa, and sigma receptors with a higher affinity for the mu receptor and lacking any mu receptor efficacy. Buprenorphine is classified as a partial agonist. It has a high affinity, but low efficacy at the mu receptor where it yields a partial effect upon binding. It also, however, possesse...
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Cannabinoid receptor agonists, such as D-tetrahydrocannabinol (D-THC), enhance the antinociceptive effects of m-opioid receptor agonists, which suggests that combining cannabinoids with opioids would improve pain treatment. Combinations with lower efficacy agonists might be preferred and could avoid adverse effects associatedwith large doses; however, it is unclear whether interactions between ...
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Cannabinoid receptor agonists, such as Δ(9)-tetrahydrocannabinol (Δ(9)-THC), enhance the antinociceptive effects of μ-opioid receptor agonists, which suggests that combining cannabinoids with opioids would improve pain treatment. Combinations with lower efficacy agonists might be preferred and could avoid adverse effects associated with large doses; however, it is unclear whether interactions b...
متن کاملEffects of yohimbine on the antinociceptive and place conditioning effects of opioid agonists in rodents.
1. The pharmacological modulation of opioid actions by drugs acting on heterologous mechanisms could be useful to overcome some of the main problems associated with the use of opiate agonists. Based on previous findings on the interactions between yohimbine and opioid drugs, we have further studied the effects of yohimbine on the antinociceptive and positive-negative reinforcing effects of morp...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1988
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1988.tb11679.x